Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287393 | 0.87 | PDE11A (0.46) | KDM4EHPGDRIPK1PDE11ANPC1 | |
| SCHEMBL5872175 | 0.87 | PDE11A (0.47) | KDM4EHPGDHSD17B10PDE11AHTT | |
| SCHEMBL8285169 | 0.86 | PDE11A (0.45) | KDM4EHPGDPDE11AMAPK14NPC1 | |
| SCHEMBL5871541 | 0.86 | PDE11A (0.46) | KDM4EHPGDHSD17B10PDE11ANPC1 | |
| SCHEMBL8285171 | 0.85 | PDE11A (0.44) | KDM4EHPGDHSD17B10PDE11ACNR2 | |
| SCHEMBL8287397 | 0.85 | PDE11A (0.46) | KDM4EHPGDHSD17B10PDE11APDE4B | |
| SCHEMBL8285180 | 0.85 | PDE11A (0.43) | KDM4EHPGDHSD17B10PDE11ACNR2 | |
| SCHEMBL8286399 | 0.84 | PDE11A (0.46) | KDM4EHPGDHSD17B10RIPK1PDE11A | |
| SCHEMBL8286396 | 0.84 | PDE11A (0.44) | KDM4EHPGDHSD17B10PDE11AHTT | |
| SCHEMBL8285155 | 0.84 | PDE11A (0.47) | KDM4EHPGDRIPK1PDE11AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |