Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285185 | 0.91 | CSNK2A2 (0.39) | ADORA3ADORA2AADORA1PDE11APOLB | |
| SCHEMBL8287397 | 0.87 | PDE11A (0.46) | PDE11AKDM4EHPGDGAAMAPT | |
| SCHEMBL8287120 | 0.86 | PDE11A (0.49) | ADORA3ADORA2AADORA1PDE11AKDM4E | |
| SCHEMBL8285193 | 0.82 | PDE11A (0.44) | ADORA3ADORA2AADORA1PDE11AKDM4E | |
| SCHEMBL8287107 | 0.79 | PDE11A (0.48) | PDE11AKDM4EHPGDGAAMAPT | |
| SCHEMBL5872175 | 0.78 | PDE11A (0.47) | PDE11AKDM4EHPGDGAAMAPT | |
| SCHEMBL8287365 | 0.78 | GRM5 (0.38) | PDE11AKDM4EGAAMAPTSMN1; SMN2 | |
| SCHEMBL5871541 | 0.78 | PDE11A (0.46) | PDE11AKDM4EHPGDGAAMAPT | |
| SCHEMBL8287393 | 0.77 | PDE11A (0.46) | PDE11AKDM4EHPGDMAPTPOLB | |
| SCHEMBL8285220 | 0.77 | PDE11A (0.43) | PDE11AKDM4EMAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |