Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285169 | 0.93 | PDE11A (0.45) | PDE11ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL8285220 | 0.91 | PDE11A (0.43) | PDE11ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL8285205 | 0.90 | MAPT (0.44) | PDE11ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL5872175 | 0.86 | PDE11A (0.47) | PDE11AGAAGFERMAPTALDH1A1 | |
| SCHEMBL8285185 | 0.85 | CSNK2A2 (0.39) | PDE11AKDRALDH1A1ADORA3ADORA2A | |
| SCHEMBL5871541 | 0.85 | PDE11A (0.46) | PDE11ARAB9ANPC1GAAGFER | |
| SCHEMBL8287397 | 0.84 | PDE11A (0.46) | PDE11ARAB9ANPC1GAAGFER | |
| SCHEMBL8287107 | 0.84 | PDE11A (0.48) | PDE11ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL8287393 | 0.84 | PDE11A (0.46) | PDE11ARAB9ANPC1KDRMAPT | |
| SCHEMBL8285223 | 0.82 | PDE11A (0.44) | PDE11AGAAGFERMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |