Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285186 | 0.91 | ADORA3 (0.37) | PDE11AGRM5ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5872175 | 0.88 | PDE11A (0.47) | CSNK2A2CSNK2BCSNK2A1PDE11ACFTR | |
| SCHEMBL8285193 | 0.85 | PDE11A (0.44) | PDE11AKDRRIPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8287107 | 0.82 | PDE11A (0.48) | PDE11AKDRRIPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5871541 | 0.81 | PDE11A (0.46) | PDE11ACFTRALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8287397 | 0.80 | PDE11A (0.46) | PDE11AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8287393 | 0.80 | PDE11A (0.46) | PDE11AKDRRIPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8285220 | 0.79 | PDE11A (0.43) | PDE11AGRM5RIPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8287365 | 0.79 | GRM5 (0.38) | PDE11AKDRGRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL8285169 | 0.79 | PDE11A (0.45) | PDE11AALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |