Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | BLK | P51451 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285273 | 0.90 | KDM4E (0.36) | GSK3BGSK3ASMN1; SMN2CDK4CCND1 | |
| SCHEMBL8287196 | 0.85 | GSK3B (0.37) | GSK3BSMN1; SMN2CDK4CCND1CCND2 | |
| SCHEMBL8287205 | 0.82 | GSK3B (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287593 | 0.81 | GSK3B (0.37) | GSK3BGSK3ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8286162 | 0.80 | GSK3B (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287945 | 0.80 | S1PR1 (0.39) | GSK3BAURKAGSK3ARHOACDK4 | |
| SCHEMBL8362929 | 0.79 | PIK3CA (0.44) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286468 | 0.79 | GSK3B (0.38) | GSK3BGSK3ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8285211 | 0.79 | RAB9A (0.42) | GSK3BAURKAGSK3ARHOARAB9A | |
| SCHEMBL5872050 | 0.78 | GAA (0.44) | GSK3BSMN1; SMN2CDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |