Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ME2 | P23368 | 3/20 | 0.37 |
| ▸ | ME1 | P48163 | 3/20 | 0.37 |
| ▸ | ME3 | Q16798 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287220 | 0.90 | CKS1B (0.41) | CKS1BSKP1SKP2MAPTPDE11A | |
| SCHEMBL8287528 | 0.89 | P2RY12 (0.44) | MAPTP2RY12KMT2AKDM4E | |
| SCHEMBL8287468 | 0.89 | P2RY12 (0.41) | MAPTPDE11AP2RY12KMT2AKDM4E | |
| SCHEMBL8285256 | 0.87 | CKS1B (0.44) | CKS1BSKP1SKP2MAPTPDE11A | |
| SCHEMBL8287232 | 0.87 | MAPT (0.43) | CKS1BSKP1SKP2MAPTPDE11A | |
| SCHEMBL8287497 | 0.86 | PDE11A (0.46) | MAPTPDE11AKMT2AKDM4E | |
| SCHEMBL8361778 | 0.86 | CDK4 (0.43) | PDE11A | |
| SCHEMBL8285282 | 0.85 | ALDH1A1 (0.42) | MAPTPDE11AKMT2AKDM4E | |
| SCHEMBL8286467 | 0.84 | PDE11A (0.44) | MAPTPDE11AKDM4E | |
| SCHEMBL8287210 | 0.83 | PDE11A (0.43) | MAPTPDE11AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |