Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362922 | 0.92 | ALDH1A1 (0.42) | ALDH1A1MAPTPDE11AKMT2ALMNA | |
| SCHEMBL8287520 | 0.89 | PDE11A (0.39) | ALDH1A1PDE11AKMT2ALMNAMEN1 | |
| SCHEMBL8287497 | 0.88 | PDE11A (0.46) | ALDH1A1MAPTKDM4EPDE11AKMT2A | |
| SCHEMBL8361778 | 0.87 | CDK4 (0.43) | ALDH1A1PDE11AHSD17B10WEE1GSK3B | |
| SCHEMBL8287223 | 0.87 | PDE11A (0.39) | ALDH1A1MAPTPDE11AKMT2ALMNA | |
| SCHEMBL8287227 | 0.87 | PDE11A (0.37) | ALDH1A1MAPTPDE11AKMT2ALMNA | |
| SCHEMBL8286467 | 0.86 | PDE11A (0.44) | ALDH1A1MAPTKDM4EPDE11ALMNA | |
| SCHEMBL8285284 | 0.85 | CKS1B (0.45) | MAPTKDM4EPDE11AKMT2A | |
| SCHEMBL8287210 | 0.85 | PDE11A (0.43) | ALDH1A1MAPTKDM4EPDE11ALMNA | |
| SCHEMBL8287220 | 0.84 | CKS1B (0.41) | MAPTPDE11AKMT2AMAPK1WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |