Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 9/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287554 | 0.92 | MEN1 (0.50) | PIK3CAPRKDCMEN1KMT2ACYP1A2 | |
| SCHEMBL8362929 | 0.88 | PIK3CA (0.44) | PIK3CAPRKDCMEN1KMT2AALK | |
| SCHEMBL8286490 | 0.87 | PIK3CA (0.47) | PIK3CAPRKDCNPC1RAB9AMAPT | |
| SCHEMBL8285310 | 0.86 | PIK3CA (0.48) | PIK3CAPRKDCMEN1KMT2AALDH1A1 | |
| SCHEMBL8287950 | 0.85 | KDM4E (0.43) | PIK3CAPRKDCMEN1KMT2AALDH1A1 | |
| SCHEMBL8287959 | 0.85 | PRKDC (0.46) | PIK3CAPRKDCMEN1KMT2AALDH1A1 | |
| SCHEMBL8285319 | 0.84 | PIK3CA (0.43) | PIK3CAPRKDCMEN1KMT2ANPC1 | |
| SCHEMBL8285309 | 0.84 | BTK (0.43) | PIK3CAPRKDCMEN1KMT2ACYP1A2 | |
| SCHEMBL8287557 | 0.83 | EGFR (0.43) | PIK3CAPRKDCMEN1KMT2ACYP1A2 | |
| SCHEMBL8287576 | 0.82 | GSK3B (0.39) | PIK3CAPRKDCMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |