Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362929 | 0.93 | PIK3CA (0.44) | BTKPIK3CAPRKDCMAT2AMAPK1 | |
| SCHEMBL8287950 | 0.91 | KDM4E (0.43) | BTKPIK3CAPRKDCMAT2AMAPK1 | |
| SCHEMBL8285319 | 0.89 | PIK3CA (0.43) | PIK3CAPRKDCMAPK1SRCFGFR1 | |
| SCHEMBL8287951 | 0.87 | BTK (0.42) | BTKPIK3CAPRKDCJAK2JAK1 | |
| SCHEMBL8287554 | 0.86 | MEN1 (0.50) | PIK3CAPRKDCMAPK1SRCFGFR1 | |
| SCHEMBL8286511 | 0.86 | MAT2A (0.38) | BTKMAT2AMAPK1PDE11AGSK3B | |
| SCHEMBL8286490 | 0.85 | PIK3CA (0.47) | PIK3CAPRKDCSRCFGFR1PLK1 | |
| SCHEMBL8287959 | 0.85 | PRKDC (0.46) | PIK3CAPRKDCMAT2ASRCFGFR1 | |
| SCHEMBL8285295 | 0.84 | PIK3CA (0.50) | PIK3CAPRKDCMAPK1PLK1MEN1 | |
| SCHEMBL8287475 | 0.83 | PIK3CA (0.45) | PIK3CAPRKDCMAT2AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |