Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285309 | 0.91 | BTK (0.43) | BTKMEN1KMT2APIK3CAPRKDC | |
| SCHEMBL8362929 | 0.91 | PIK3CA (0.44) | MAPTBTKMEN1KMT2APIK3CA | |
| SCHEMBL8287959 | 0.87 | PRKDC (0.46) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8286490 | 0.87 | PIK3CA (0.47) | KDM4EMAPTNPC1RAB9APIK3CA | |
| SCHEMBL8287951 | 0.85 | BTK (0.42) | MAPTBTKMEN1KMT2APIK3CA | |
| SCHEMBL8285319 | 0.85 | PIK3CA (0.43) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8285295 | 0.85 | PIK3CA (0.50) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8287554 | 0.82 | MEN1 (0.50) | KDM4EMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8287475 | 0.81 | PIK3CA (0.45) | KMT2AALDH1A1PIK3CAPRKDCFGFR1 | |
| SCHEMBL8287504 | 0.81 | PRKDC (0.46) | NPC1RAB9APIK3CAPRKDCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |