Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KLRK1 | P26718 | 2/20 | 0.37 |
| ▸ | MICA | Q29983 | 2/20 | 0.37 |
| ▸ | RAET1L | Q5VY80 | 2/20 | 0.37 |
| ▸ | MTTP | P55157 | 6/20 | 0.35 |
| ▸ | TACR3 | P29371 | 8/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824992 | 0.91 | KCNH2 (0.48) | KCNH2KLRK1MICARAET1LMTTP | |
| SCHEMBL827540 | 0.91 | KLRK1 (0.36) | KCNH2KLRK1MICARAET1LMTTP | |
| SCHEMBL827539 | 0.82 | KCNH2 (0.32) | KCNH2KLRK1MICARAET1LTACR3 | |
| SCHEMBL858133 | 0.80 | KCNH2 (0.41) | KCNH2MTTPTACR3TACR2KDM4E | |
| SCHEMBL15841754 | 0.79 | HSD17B10 (0.33) | HSD17B10 | |
| SCHEMBL3060734 | 0.79 | CYP3A4 (0.45) | KCNH2CYP1A2CYP3A4 | |
| SCHEMBL31737531 | 0.78 | F2 (0.37) | KCNH2KLRK1MICARAET1LMTTP | |
| SCHEMBL16223451 | 0.76 | KCNH2 (0.45) | KCNH2PREPFAPCYP3A4 | |
| SCHEMBL1478629 | 0.76 | KCNH2 (0.45) | KCNH2PREPFAPCYP3A4 | |
| SCHEMBL31738241 | 0.74 | F2 (0.37) | KCNH2KLRK1MICARAET1LMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417126-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-07-02 | — | — | EP | claimed |
| US-20100260708-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-10-14 | — | — | US | claimed |
| EP-2417126-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-07-02 | — | — | EP | disclosed |
| US-8143301-B2 | Hepatitis C virus inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100260708-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100260708-A1 | Hepatitis C Virus Inhibitors | HAVCR2, PYGL, HCCS | KCNH2 4523/4885KLRK1 1182/4885MICA 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.