Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285288 | 0.88 | NPC1 (0.36) | ALDH1A1LMNAHTTGAAPDE11A | |
| SCHEMBL8285360 | 0.88 | MAPT (0.41) | KDM4EALDH1A1LMNAHTTNPSR1 | |
| SCHEMBL8286554 | 0.87 | ALDH1A1 (0.35) | ALDH1A1LMNAGAAPDE11AMAT2A | |
| SCHEMBL8287501 | 0.85 | GAA (0.39) | KDM4EALDH1A1LMNAHTTGAA | |
| SCHEMBL8286175 | 0.84 | GAA (0.36) | KDM4EALDH1A1LMNAHTTGAA | |
| SCHEMBL8285362 | 0.84 | GAA (0.36) | KDM4EALDH1A1LMNAHTTGAA | |
| SCHEMBL8287276 | 0.84 | MAT2A (0.40) | KDM4EHTTGAAMAT2ASMN1; SMN2 | |
| SCHEMBL8287594 | 0.83 | SETDB1 (0.37) | KDM4EALDH1A1LMNAHTTNPSR1 | |
| SCHEMBL8285357 | 0.82 | KCNJ6 (0.36) | ALDH1A1LMNAGAAPDE11ACDK4 | |
| SCHEMBL8286187 | 0.82 | GAA (0.36) | KDM4EALDH1A1LMNAHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |