Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286163 | 0.87 | BRAF (0.40) | CYP1A2CYP2C9CYP2C19MAPK1GAA | |
| SCHEMBL8286166 | 0.85 | GAA (0.37) | SMN1; SMN2MAPK1GAAHPGDPDE11A | |
| SCHEMBL8287246 | 0.82 | GAA (0.39) | SMN1; SMN2MAPK1GAAHPGDPDE11A | |
| SCHEMBL8288000 | 0.81 | PKM (0.35) | CYP1A2CYP2C9CYP2C19SMN1; SMN2MAPK1 | |
| SCHEMBL8286454 | 0.81 | GAA (0.38) | CYP1A2SMN1; SMN2MAPK1GAAHPGD | |
| SCHEMBL8287281 | 0.81 | GAA (0.38) | SMN1; SMN2MAPK1GAAHPGDPDE11A | |
| SCHEMBL5872272 | 0.81 | GAA (0.38) | SMN1; SMN2MAPK1GAAHPGDPDE11A | |
| SCHEMBL8287214 | 0.81 | GAA (0.44) | SMN1; SMN2MAPK1GAAHPGDPDE11A | |
| SCHEMBL8287251 | 0.79 | GAA (0.36) | SMN1; SMN2MAPK1GAAHPGDPDE11A | |
| SCHEMBL8287991 | 0.79 | GAA (0.39) | SMN1; SMN2MAPK1GAAHPGDPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |