Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286187 | 0.88 | GAA (0.36) | PKMHTTSMN1; SMN2CDK4CCND1 | |
| SCHEMBL8287501 | 0.85 | GAA (0.39) | HTTSMN1; SMN2CDK4CCND1CCND2 | |
| SCHEMBL8285362 | 0.84 | GAA (0.36) | HTTSMN1; SMN2CDK4CCND1CCND2 | |
| SCHEMBL8286175 | 0.84 | GAA (0.36) | HTTSMN1; SMN2CDK4CCND1CCND2 | |
| SCHEMBL8285288 | 0.84 | NPC1 (0.36) | HTTSMN1; SMN2CDK4CCND1CCND2 | |
| SCHEMBL8285360 | 0.84 | MAPT (0.41) | HTTCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286554 | 0.83 | ALDH1A1 (0.35) | CDK4CCND1CCND2CCND3MAPT | |
| SCHEMBL8285357 | 0.82 | KCNJ6 (0.36) | CDK4CCND1CCND2CCND3GAA | |
| SCHEMBL8285350 | 0.82 | GAA (0.36) | HTTSMN1; SMN2CDK4CCND1CCND2 | |
| SCHEMBL8286161 | 0.81 | CYP1A2 (0.36) | SMN1; SMN2CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |