Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358810 | 0.87 | GSK3B (0.36) | ALDH1A1LMNAGSK3BMAPK8CSF1R | |
| SCHEMBL8286206 | 0.86 | NPC1 (0.38) | ALDH1A1LMNAL3MBTL1GSK3BPIK3CA | |
| SCHEMBL8286126 | 0.84 | MAPK8 (0.46) | ALDH1A1LMNAL3MBTL1GSK3BMAPK8 | |
| SCHEMBL8285347 | 0.83 | MAPK8 (0.37) | ALDH1A1GSK3BGABRA5MAPK8CSF1R | |
| SCHEMBL8287580 | 0.83 | GSK3B (0.38) | ALDH1A1GSK3BMAPK8CSF1RMAPK9 | |
| SCHEMBL8288002 | 0.81 | GSK3B (0.36) | ALDH1A1LMNAGSK3BMAPK8CSF1R | |
| SCHEMBL8287541 | 0.79 | GSK3B (0.41) | ALDH1A1LMNAGSK3BCSF1R | |
| SCHEMBL8288004 | 0.78 | MAPK8 (0.49) | ALDH1A1LMNAMAPK8MAPK9 | |
| SCHEMBL8285356 | 0.78 | GSK3B (0.40) | ALDH1A1LMNAGSK3BCSF1RBUB1 | |
| SCHEMBL8287492 | 0.77 | GSK3B (0.40) | ALDH1A1LMNAGSK3BPIK3CAPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |