Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286206 | 0.88 | NPC1 (0.38) | MAPK8GSK3BALDH1A1CSF1RMEN1 | |
| SCHEMBL8358810 | 0.87 | GSK3B (0.36) | MAPK8GSK3BALDH1A1CSF1RMEN1 | |
| SCHEMBL8286138 | 0.83 | MAT2A (0.43) | MAPK8GABRA5GSK3BMAT2APOLB | |
| SCHEMBL8286164 | 0.83 | ALDH1A1 (0.34) | MAPK8GABRA5GSK3BALDH1A1CSF1R | |
| SCHEMBL8287580 | 0.83 | GSK3B (0.38) | MAPK8GSK3BMAT2AALDH1A1KDM4E | |
| SCHEMBL8288002 | 0.81 | GSK3B (0.36) | MAPK8GSK3BMAT2APOLBALDH1A1 | |
| SCHEMBL8287541 | 0.79 | GSK3B (0.41) | GSK3BMAT2AALDH1A1HPGDCSF1R | |
| SCHEMBL8285356 | 0.78 | GSK3B (0.40) | GSK3BMAT2AALDH1A1HPGDCSF1R | |
| SCHEMBL8287492 | 0.77 | GSK3B (0.40) | GSK3BMAT2AALDH1A1KDM4EHPGD | |
| SCHEMBL8288004 | 0.76 | MAPK8 (0.49) | MAPK8ALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |