Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358810 | 0.91 | GSK3B (0.36) | ALDH1A1MEN1KMT2AUSP2CYP1A2 | |
| SCHEMBL8285347 | 0.88 | MAPK8 (0.37) | NPC1ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL8286164 | 0.86 | ALDH1A1 (0.34) | L3MBTL1PIK3CAPRKDCALDH1A1GSK3B | |
| SCHEMBL8287580 | 0.86 | GSK3B (0.38) | MAPTALDH1A1GAACYP1A2GSK3B | |
| SCHEMBL8288002 | 0.84 | GSK3B (0.36) | ALDH1A1GAACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8287541 | 0.82 | GSK3B (0.41) | NPC1SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL8286135 | 0.81 | MAT2A (0.46) | NPC1RAB9AL3MBTL1SMN1; SMN2PKM | |
| SCHEMBL8285356 | 0.81 | GSK3B (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL8287492 | 0.80 | GSK3B (0.40) | SMN1; SMN2MAPTPIK3CAPRKDCALDH1A1 | |
| SCHEMBL8288004 | 0.79 | MAPK8 (0.49) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |