Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286224 | 0.83 | SLC18A3 (0.37) | SLC18A3POLBHTTALDH1A1OPRL1 | |
| SCHEMBL8285370 | 0.82 | SLC18A3 (0.36) | SLC18A3OPRM1OPRK1POLBHTT | |
| SCHEMBL8286582 | 0.81 | SLC18A3 (0.36) | SLC18A3POLBHTTALDH1A1OPRL1 | |
| SCHEMBL8285372 | 0.75 | SLC18A3 (0.50) | SLC18A3OPRM1OPRD1OPRK1HTT | |
| SCHEMBL8287289 | 0.74 | SLC18A3 (0.40) | SLC18A3HTTALDH1A1MAPTHPGD | |
| SCHEMBL8892930 | 0.71 | ALDH1A1 (0.62) | OPRM1OPRD1OPRK1ALDH1A1OPRL1 | |
| SCHEMBL12563615 | 0.70 | TDP1 (0.40) | ALDH1A1OPRL1MAPTCYP2D6KMT2A | |
| SCHEMBL23595723 | 0.68 | SLC18A3 (0.57) | SLC18A3POLBALDH1A1MAPTKMT2A | |
| SCHEMBL10562193 | 0.68 | SLC18A3 (0.57) | SLC18A3POLBALDH1A1MAPTKMT2A | |
| SCHEMBL491782 | 0.68 | SLC18A3 (0.57) | SLC18A3POLBALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040166-A1 | TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |