Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286224 | 0.86 | SLC18A3 (0.37) | SLC18A3OPRL1ALDH1A1HTTPOLB | |
| SCHEMBL8286229 | 0.81 | SLC18A3 (0.37) | SLC18A3OPRL1ALDH1A1HTTPOLB | |
| SCHEMBL8285370 | 0.81 | SLC18A3 (0.36) | SLC18A3ALDH1A1HTTPOLB | |
| SCHEMBL14573339 | 0.74 | SLC6A9 (0.43) | OPRL1 | |
| SCHEMBL8285372 | 0.74 | SLC18A3 (0.50) | SLC18A3OPRL1ALDH1A1HTTTSHR | |
| SCHEMBL12397058 | 0.72 | OPRL1 (0.34) | OPRL1ALDH1A1 | |
| SCHEMBL8287289 | 0.72 | SLC18A3 (0.40) | SLC18A3ALDH1A1HTT | |
| SCHEMBL476361 | 0.71 | OPRL1 (0.34) | OPRL1ALDH1A1 | |
| SCHEMBL8288001 | 0.70 | MAPK1 (0.43) | SLC18A3ALDH1A1TSHR | |
| SCHEMBL8287297 | 0.68 | SLC18A3 (0.42) | SLC18A3OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040166-A1 | TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |