Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872091 | 0.85 | MAT2A (0.54) | ADORA1ADORA2AMAT2ASMN1; SMN2TSHR | |
| SCHEMBL8287872 | 0.83 | MAT2A (0.47) | ADORA1MAT2APOLBMAPTSMN1; SMN2 | |
| SCHEMBL8286340 | 0.82 | GAA (0.50) | ADORA1MAT2AMAPTSMN1; SMN2HTT | |
| SCHEMBL8287837 | 0.81 | MAT2A (0.54) | ADORA1MAT2APOLBMAPTSMN1; SMN2 | |
| SCHEMBL8285115 | 0.80 | BPTF (0.36) | ADORA1ADORA2APOLBMAPTSMN1; SMN2 | |
| SCHEMBL8287867 | 0.79 | MAT2A (0.50) | ADORA1ADORA2AMAT2APOLBMAPT | |
| SCHEMBL8287894 | 0.78 | MAT2A (0.49) | ADORA1ADORA2AMAT2APOLBMAPT | |
| SCHEMBL8287369 | 0.78 | MAT2A (0.52) | MAT2APOLBMAPTSMN1; SMN2TSHR | |
| SCHEMBL8287862 | 0.77 | PDE11A (0.42) | MAT2AMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL8287165 | 0.76 | HPGD (0.39) | ADORA1ADORA2ARXFP1PDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |