Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAT2A | P31153 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872091 | 0.92 | MAT2A (0.54) | GAAHPGDSMN1; SMN2MAT2ALMNA | |
| SCHEMBL8287899 | 0.89 | LMNA (0.49) | GAAHPGDSMN1; SMN2MAT2AMAPT | |
| SCHEMBL8287837 | 0.88 | MAT2A (0.54) | SMN1; SMN2MAT2AMAPTLMNAALDH1A1 | |
| SCHEMBL8286345 | 0.85 | MAT2A (0.50) | HPGDSMN1; SMN2MAT2AALDH1A1HTT | |
| SCHEMBL8287894 | 0.84 | MAT2A (0.49) | GAAHPGDSMN1; SMN2MAT2AMAPT | |
| SCHEMBL8286343 | 0.82 | ADORA1 (0.43) | SMN1; SMN2MAT2AMAPTHTTADORA1 | |
| SCHEMBL8287872 | 0.82 | MAT2A (0.47) | SMN1; SMN2MAT2AMAPTLMNAALDH1A1 | |
| SCHEMBL8285127 | 0.82 | PDE11A (0.44) | GAAHPGDSMN1; SMN2MAT2ALMNA | |
| SCHEMBL8287369 | 0.81 | MAT2A (0.52) | SMN1; SMN2MAT2AMAPTLMNAALDH1A1 | |
| SCHEMBL8287867 | 0.81 | MAT2A (0.50) | MAT2AMAPTNPSR1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |