Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 12/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 12/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 12/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 12/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 12/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 12/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285166 | 0.87 | PDE11A (0.60) | PDE11AALDH1A1 | |
| SCHEMBL8287889 | 0.86 | PDE11A (0.73) | PDE11AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8286344 | 0.86 | PDE11A (0.64) | PDE11AALDH1A1 | |
| SCHEMBL8286346 | 0.86 | PDE11A (0.61) | PDE11AALDH1A1 | |
| SCHEMBL8286342 | 0.85 | PDE11A (0.60) | PDE11AALDH1A1 | |
| SCHEMBL5872109 | 0.83 | PDE11A (0.75) | PDE11AALDH1A1 | |
| SCHEMBL5871598 | 0.83 | PDE11A (0.58) | PDE11AALDH1A1 | |
| SCHEMBL5871831 | 0.82 | PDE11A (0.57) | PDE11AALDH1A1 | |
| SCHEMBL8287870 | 0.81 | PDE11A (0.56) | PDE11AALDH1A1 | |
| SCHEMBL8285164 | 0.80 | PDE11A (0.55) | PDE11AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |