Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287393 | 0.89 | PDE11A (0.46) | PDE11ARIPK1POLBTP53HPGD | |
| SCHEMBL5872175 | 0.88 | PDE11A (0.47) | PDE11APOLBGSK3BHPGDKDM4E | |
| SCHEMBL5871541 | 0.87 | PDE11A (0.46) | PDE11APOLBGSK3BTP53HPGD | |
| SCHEMBL8287397 | 0.86 | PDE11A (0.46) | PDE11APOLBGSK3BHPGDKDM4E | |
| SCHEMBL8286396 | 0.86 | PDE11A (0.44) | PDE11APOLBHPGDKDM4EHSD17B10 | |
| SCHEMBL8285169 | 0.85 | PDE11A (0.45) | PDE11APOLBGSK3BTP53HPGD | |
| SCHEMBL8287518 | 0.84 | PDE11A (0.44) | PDE11APOLBGSK3BHPGDKDM4E | |
| SCHEMBL8285223 | 0.84 | PDE11A (0.44) | PDE11APOLBGSK3BHPGDKDM4E | |
| SCHEMBL8287388 | 0.84 | MAPT (0.48) | PDE11ARIPK1HPGDKDM4EGAA | |
| SCHEMBL8286397 | 0.84 | KDM4E (0.49) | PDE11ARIPK1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |