Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286452 | 0.89 | PDE11A (0.44) | PDE11AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8285238 | 0.88 | PDE11A (0.49) | PDE11AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8287405 | 0.86 | OPRK1 (0.53) | TSHRKCNJ6KCNJ5KCNJ3PDE11A | |
| SCHEMBL8287830 | 0.86 | PDE11A (0.48) | TSHRPDE11AKDM4EMAPTMEN1 | |
| SCHEMBL8285244 | 0.84 | PDE11A (0.44) | TSHRKCNJ6KCNJ5KCNJ3PDE11A | |
| SCHEMBL8286439 | 0.84 | MAPT (0.52) | PDE11AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8285149 | 0.83 | PDE11A (0.47) | PDE11AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8286440 | 0.82 | PDE11A (0.48) | PDE11AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL8285163 | 0.82 | POLB (0.50) | TSHRPDE11AKDM4EMAPTMEN1 | |
| SCHEMBL8285359 | 0.81 | KDM4E (0.47) | TSHRKCNJ6KCNJ5KCNJ3PDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |