Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285358 | 0.89 | GAA (0.43) | KDM4EADORA3NPC1RAB9ALMNA | |
| SCHEMBL8287944 | 0.88 | GAA (0.43) | KDM4ECYP1A2TSHRATMNPC1 | |
| SCHEMBL8286535 | 0.86 | OPRK1 (0.45) | TSHRKCNJ6KCNJ5KCNJ3SLC2A1 | |
| SCHEMBL8358804 | 0.84 | MAT2A (0.41) | KDM4ETSHRKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8287217 | 0.84 | RIPK1 (0.43) | KDM4ETSHRKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL5871645 | 0.83 | GAA (0.42) | KDM4ECYP1A2TSHRKCNJ6KCNJ5 | |
| SCHEMBL8286573 | 0.82 | GAA (0.42) | KDM4ECYP1A2TSHRATMNPC1 | |
| SCHEMBL5872108 | 0.82 | GAA (0.44) | KDM4ECYP1A2TSHRATMNPC1 | |
| SCHEMBL5872094 | 0.82 | PDE11A (0.40) | KDM4ECYP1A2TSHRKCNJ6KCNJ5 | |
| SCHEMBL8285272 | 0.82 | PDE11A (0.37) | KDM4ETSHRNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |