Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285278 | 0.92 | MAPK1 (0.38) | GSK3BGAAHPGDMAPK1HTT | |
| SCHEMBL8286511 | 0.89 | MAT2A (0.38) | GSK3BCSF1RMAPK1ADORA3ALDH1A1 | |
| SCHEMBL8285319 | 0.86 | PIK3CA (0.43) | GSK3BMAPTGAAHPGDMAPK1 | |
| SCHEMBL5872050 | 0.84 | GAA (0.44) | GSK3BMAPTGAAHPGDMAPK1 | |
| SCHEMBL8286496 | 0.83 | FYN (0.37) | GSK3BALDH1A1POLBNPC1CDK4 | |
| SCHEMBL8285307 | 0.83 | ATR (0.42) | GSK3BMAPTTP53CSF1RALDH1A1 | |
| SCHEMBL8287576 | 0.81 | GSK3B (0.39) | GSK3BMAPTGAAHPGDMAPK1 | |
| SCHEMBL8362929 | 0.80 | PIK3CA (0.44) | GSK3BMAPTGAAHPGDMAPK1 | |
| SCHEMBL8286490 | 0.80 | PIK3CA (0.47) | GSK3BMAPTTP53NPSR1NPC1 | |
| SCHEMBL8286508 | 0.80 | LOXL3 (0.42) | GAAHPGDCYP2C9ADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |