Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286365 | 0.91 | PDE11A (0.46) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8287553 | 0.83 | PDE11A (0.36) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8286368 | 0.80 | PDE11A (0.44) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8285163 | 0.80 | POLB (0.50) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8361765 | 0.79 | GAA (0.45) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8285238 | 0.79 | PDE11A (0.49) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL5871846 | 0.79 | PDE11A (0.49) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8286440 | 0.78 | PDE11A (0.48) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8287154 | 0.78 | PDE11A (0.48) | PDE11AGAAMAPK1HPGDKDM4E | |
| SCHEMBL8287463 | 0.77 | SMN1; SMN2 (0.48) | GAAMAPK1KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |