Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 9/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287549 | 0.90 | PDE11A (0.39) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL8287151 | 0.83 | PDE11A (0.42) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL7036674 | 0.81 | ALDH1A1 (0.41) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL8287221 | 0.79 | APLNR (0.42) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL5872108 | 0.79 | GAA (0.44) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL5872104 | 0.78 | GAA (0.45) | PDE11AGAAHPGDMAPK1SMN1; SMN2 | |
| SCHEMBL8287944 | 0.78 | GAA (0.43) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL7046873 | 0.78 | PDE11A (0.37) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL8286573 | 0.77 | GAA (0.42) | PDE11AGAAHPGDMAPK1HTT | |
| SCHEMBL8287934 | 0.77 | MAT2A (0.43) | PDE11AGAAHPGDMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |