Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361765 | 0.91 | GAA (0.45) | SMN1; SMN2GAAKDM4EMAPK1ALDH1A1 | |
| SCHEMBL8286356 | 0.91 | CYP3A4 (0.41) | SMN1; SMN2USP2GAAMAPTKDM4E | |
| SCHEMBL8286358 | 0.88 | USP2 (0.46) | SMN1; SMN2USP2KDM4EKMT2AALDH1A1 | |
| SCHEMBL8286357 | 0.87 | ALDH1A1 (0.43) | SMN1; SMN2USP2MAPTKDM4EKMT2A | |
| SCHEMBL8286368 | 0.84 | PDE11A (0.44) | SMN1; SMN2GAAMAPTKDM4ELMNA | |
| SCHEMBL8287419 | 0.83 | PDE11A (0.51) | SMN1; SMN2USP2GAAMAPTKDM4E | |
| SCHEMBL8286548 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2USP2GAAMAPTKMT2A | |
| SCHEMBL8286380 | 0.82 | PDE11A (0.44) | SMN1; SMN2GAAMAPTKDM4EKMT2A | |
| SCHEMBL8287405 | 0.82 | OPRK1 (0.53) | SMN1; SMN2USP2GAAMAPTKDM4E | |
| SCHEMBL8287417 | 0.81 | HTT (0.47) | SMN1; SMN2USP2MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |