Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287156 | 0.93 | MAT2A (0.50) | MAT2AMAPK8MAPK9MAPK10RXFP1 | |
| SCHEMBL8287392 | 0.81 | MAPK8 (0.47) | MAT2AMAPK8MAPK9MAPK10RXFP1 | |
| SCHEMBL8285234 | 0.80 | MAT2A (0.47) | MAT2AMAPK8MAPK9MAPK10RXFP1 | |
| SCHEMBL8286133 | 0.80 | MAT2A (0.50) | MAT2AMAPK8MAPK9MAPK10RXFP1 | |
| SCHEMBL8287180 | 0.80 | MAT2A (0.45) | MAT2AMAPK8MAPK9MAPK10RXFP1 | |
| SCHEMBL8286135 | 0.78 | MAT2A (0.46) | MAT2AMAPK8MAPK9MAPK10RXFP1 | |
| SCHEMBL8285354 | 0.78 | GSK3B (0.39) | MAT2AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL5871674 | 0.77 | SMN1; SMN2 (0.50) | MAT2AMAPK8MAPK9MAPK10SMN1; SMN2 | |
| SCHEMBL29305636 | 0.77 | MAT2A (0.51) | MAT2AMAPK8MAPK9MAPK10SMN1; SMN2 | |
| SCHEMBL7059471 | 0.76 | MEN1 (0.41) | MAT2AMAPK8MAPK9MAPK10GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |