Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286133 | 0.89 | MAT2A (0.50) | MAT2AMAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8286138 | 0.88 | MAT2A (0.43) | MAT2AMAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8287392 | 0.85 | MAPK8 (0.47) | MAT2AMAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8286136 | 0.83 | MAPK8 (0.46) | MAT2AMAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8286126 | 0.83 | MAPK8 (0.46) | MAT2AMAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8285234 | 0.83 | MAT2A (0.47) | MAT2AMAPK8MAPK9MAPK10SMN1; SMN2 | |
| SCHEMBL8286206 | 0.81 | NPC1 (0.38) | MAPK8NPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL8287156 | 0.80 | MAT2A (0.50) | MAT2AMAPK8MAPK9MAPK10SMN1; SMN2 | |
| SCHEMBL8285229 | 0.78 | MAPK8 (0.50) | MAT2AMAPK8MAPK9MAPK10SMN1; SMN2 | |
| SCHEMBL8287183 | 0.78 | MAT2A (0.48) | MAT2AMAPK8MAPK9MAPK10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |