Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286342 | 0.86 | PDE11A (0.60) | PDE11AKDM4EGAAL3MBTL1ACHE | |
| SCHEMBL8286346 | 0.85 | PDE11A (0.61) | PDE11AKDM4EGAAL3MBTL1ACHE | |
| SCHEMBL8286344 | 0.79 | PDE11A (0.64) | PDE11AKDM4EL3MBTL1ALDH1A1POLB | |
| SCHEMBL8287913 | 0.79 | PDE11A (0.45) | PDE11AKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL8285166 | 0.79 | PDE11A (0.60) | PDE11AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL5872109 | 0.77 | PDE11A (0.75) | PDE11AKDM4EGAAALDH1A1HPGD | |
| SCHEMBL5871598 | 0.77 | PDE11A (0.58) | PDE11AKDM4EALDH1A1POLBHPGD | |
| SCHEMBL5871831 | 0.76 | PDE11A (0.57) | PDE11AALDH1A1POLBMAPTCDK4 | |
| SCHEMBL8287870 | 0.75 | PDE11A (0.56) | PDE11AKDM4EALDH1A1MAPTCDK4 | |
| SCHEMBL8285164 | 0.74 | PDE11A (0.55) | PDE11AKDM4EALDH1A1MAPTCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |