Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287497 | 0.90 | PDE11A (0.46) | CDK4CDK6KDRPDE11APOLB | |
| SCHEMBL8286467 | 0.90 | PDE11A (0.44) | CDK4PDE11APOLBALDH1A1MAPK8 | |
| SCHEMBL8287210 | 0.89 | PDE11A (0.43) | KDRPDE11APOLBALDH1A1MAPK8 | |
| SCHEMBL8361778 | 0.88 | CDK4 (0.43) | CDK4KDRPDE11AALDH1A1CYP1A2 | |
| SCHEMBL8287452 | 0.88 | PDE11A (0.55) | PDE11AKDM1AALDH1A1MAPK8HIF1A | |
| SCHEMBL8362922 | 0.85 | ALDH1A1 (0.42) | PDE11APOLBKMT2AALDH1A1MAPK8 | |
| SCHEMBL8287220 | 0.84 | CKS1B (0.41) | CDK4PDE11AKMT2AMAPK8ALOX15 | |
| SCHEMBL8287223 | 0.84 | PDE11A (0.39) | PDE11APOLBKMT2AALDH1A1HTR6 | |
| SCHEMBL8285282 | 0.83 | ALDH1A1 (0.42) | PDE11APOLBKMT2AALDH1A1HSD17B10 | |
| SCHEMBL8287232 | 0.83 | MAPT (0.43) | PDE11APOLBALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |