Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286454 | 0.89 | GAA (0.38) | MAPTMEN1KMT2AABL1CYP1A2 | |
| SCHEMBL8287990 | 0.86 | USP2 (0.36) | MEN1KMT2ACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL8286163 | 0.84 | BRAF (0.40) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL8362692 | 0.82 | CYP1A2 (0.40) | MAPTMEN1KMT2AABL1CYP1A2 | |
| SCHEMBL8287214 | 0.80 | GAA (0.44) | MAPTMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8287380 | 0.80 | CYP1A2 (0.46) | MAPTMEN1KMT2ASRCABL1 | |
| SCHEMBL8286187 | 0.79 | GAA (0.36) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL8287246 | 0.79 | GAA (0.39) | MAPTMEN1KMT2ASRCCYP3A4 | |
| SCHEMBL8286161 | 0.78 | CYP1A2 (0.36) | MEN1KMT2ACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL8287501 | 0.78 | GAA (0.39) | MAPTMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |