SCHEMBL8287380

SCHEMBL8287380

COc1ccc(-c2cc3c(=O)cc(Nc4ccccc4)n(-c4ccccc4)c3nc2C)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 0.46
CYP3A4 P08684 6/20 0.46
USP2 O75604 6/20 0.46
TSHR P16473 4/20 0.46
CYP2C9 P11712 4/20 0.46
CASP1 P29466 3/20 0.46
CASP7 P55210 3/20 0.46
ALDH1A1 P00352 7/20 0.43
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
CFTR P13569 1/20 0.41
CYP2C19 P33261 3/20 0.41
CLK4 Q9HAZ1 1/20 0.41
RAB9A P51151 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ACP1 P24666 1/20 0.40
MAPT P10636 3/20 0.40
MAPK1 P28482 2/20 0.39
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8285224 0.91 PDE11A (0.41) TSHRCYP2C9ALDH1A1MEN1KMT2A
SCHEMBL8285227 0.88 PDE11A (0.40) CYP1A2CYP3A4USP2TSHRCASP1
SCHEMBL8286442 0.83 ALDH1A1 (0.42) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL8287837 0.82 MAT2A (0.54) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL8285191 0.82 EGLN1 (0.41) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL5871894 0.81 PDE11A (0.43) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL8287987 0.80 MAPT (0.41) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL8287451 0.80 PDE11A (0.42) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL8286129 0.79 PDE11A (0.39) CYP1A2CYP3A4USP2TSHRCYP2C9
SCHEMBL8285194 0.79 ALDH1A1 (0.43) CYP1A2CYP3A4USP2TSHRCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005091857-A2 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2005-10-06 WO disclosed
WO-2003027112-A1 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS BAYER PHARMACEUTICALS CORPORATION (US) 2003-04-03 WO disclosed