Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.69 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.69 |
| ▸ | GCGR | P47871 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289724 | 0.87 | ALDH1A1 (0.59) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL16689136 | 0.85 | GCGR (0.66) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL2649274 | 0.79 | GCGR (0.76) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL2647850 | 0.79 | GCGR (1.00) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL31075000 | 0.78 | MAPT (0.96) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL2648864 | 0.78 | GCGR (0.74) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL2647883 | 0.78 | GCGR (0.73) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL3282241 | 0.78 | MAPT (0.71) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL13210588 | 0.78 | HPGD (0.68) | MAPTNPSR1SAE1UBA2GCGR | |
| SCHEMBL2648446 | 0.77 | MAPT (0.71) | MAPTNPSR1SAE1UBA2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |