Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288594 | 0.92 | TP53 (0.59) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL22692834 | 0.88 | ALDH1A1 (0.68) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL4210260 | 0.87 | POLB (0.74) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL21045380 | 0.81 | MAPT (0.68) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL21045545 | 0.80 | ALDH1A1 (0.67) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL21045548 | 0.80 | ALDH1A1 (0.72) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL21082792 | 0.79 | ALDH1A1 (0.62) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL8288704 | 0.79 | ALDH1A1 (0.72) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL22404679 | 0.78 | ALDH1A1 (0.63) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL22692837 | 0.78 | ALDH1A1 (0.67) | MAPTKMT2AMEN1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |