Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212750 | 1.00 | ELANE (0.68) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8222586 | 0.92 | ELANE (0.80) | ELANECYP2C9CYP3A4 | |
| SCHEMBL394825 | 0.91 | ELANE (0.73) | ELANECYP2C9CYP3A4 | |
| SCHEMBL3482367 | 0.91 | ELANE (0.73) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13540746 | 0.90 | ELANE (0.84) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1243924 | 0.90 | ELANE (0.84) | ELANECYP2C9CYP3A4 | |
| SCHEMBL9914409 | 0.89 | ELANE (0.83) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13542608 | 0.89 | ELANE (0.79) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8279992 | 0.89 | ELANE (0.67) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8281006 | 0.89 | ELANE (0.67) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730121-B1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER IP GMBH (DE) | 2013-08-07 | — | — | EP | disclosed |
| US-8343987-B2 | Heterocyclic derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-01-01 | — | — | US | disclosed |
| US-8343987-B2 | Heterocyclic derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-01-01 | — | — | US | disclosed |
| US-7893073-B2 | Heterocyclic derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-02-22 | — | — | US | disclosed |
| US-7893073-B2 | Heterocyclic derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-02-22 | — | — | US | disclosed |
| US-20100184788-A1 | HETEROCYCLIC DERIVATIVES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-07-22 | — | — | US | disclosed |
| US-20100184788-A1 | HETEROCYCLIC DERIVATIVES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-07-22 | — | — | US | disclosed |
| US-20080021053-A1 | Heterocyclic Derivatives | BAYER HEALTHCARE AG (DE) | 2008-01-24 | — | — | US | disclosed |
| US-20080021053-A1 | Heterocyclic Derivatives | BAYER HEALTHCARE AG (DE) | 2008-01-24 | — | — | US | disclosed |
| WO-2005082863-A2 | 1,4 DIARYL-DIHYDROPYRIMIDIN-2 ONES AND THEIR USE AS A HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021053-A1 | Heterocyclic Derivatives | TNNI3, CYP11B2, TNNT2 | ELANE 132/4885CYP2C9 838/4885CYP3A4 650/4885 |
| US-20100184788-A1 | HETEROCYCLIC DERIVATIVES | TNNI3, TNNT2, CYP11B2 | ELANE 132/4885CYP2C9 854/4885CYP3A4 664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.