Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671592 | 0.87 | MAPT (0.72) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL8457805 | 0.85 | MAPT (0.71) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL8289684 | 0.85 | MAPT (0.70) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL4776005 | 0.83 | MAPT (1.00) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL3576636 | 0.79 | MAPT (0.73) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL2778266 | 0.74 | GAA (0.65) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL5025179 | 0.74 | MAPK1 (0.65) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL5467672 | 0.73 | ADORA1 (0.57) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL9039352 | 0.72 | LMNA (0.67) | MAPTGAAHTTLMNAALOX15 | |
| SCHEMBL3584706 | 0.71 | NPSR1 (0.57) | MAPTGAAHTTLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |