Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | CASP3 | P42574 | 1/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289498 | 0.99 | FLT3 (0.79) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL7902040 | 0.88 | GRIN2C (0.78) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL14366842 | 0.87 | FLT3 (1.00) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL8289526 | 0.87 | RAB9A (0.95) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL8289853 | 0.87 | FLT3 (0.97) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL8288696 | 0.87 | FLT3 (0.73) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL8289672 | 0.85 | FLT3 (0.97) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL8290663 | 0.85 | FLT3 (1.00) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL8289442 | 0.85 | FLT3 (0.74) | FLT3POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL5453475 | 0.85 | ANO1 (0.65) | FLT3POLBNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |