Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD2 | Q8N5K1 | 15/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289765 | 0.91 | ALDH1A1 (0.83) | CISD2ALDH1A1KDM4ERXFP1NPC1 | |
| SCHEMBL30300650 | 0.89 | CISD2 (1.00) | CISD2RXFP1NPC1MAPTRAB9A | |
| SCHEMBL25106671 | 0.89 | CISD2 (1.00) | CISD2RXFP1NPC1MAPTRAB9A | |
| SCHEMBL8290343 | 0.79 | CISD2 (1.00) | CISD2ALDH1A1 | |
| SCHEMBL30300675 | 0.79 | CISD2 (1.00) | CISD2ALDH1A1 | |
| SCHEMBL25106674 | 0.79 | CISD2 (1.00) | CISD2ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL25106672 | 0.78 | CISD2 (1.00) | CISD2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL25106698 | 0.78 | CISD2 (1.00) | CISD2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL25106682 | 0.77 | CISD2 (1.00) | CISD2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL25106689 | 0.77 | CISD2 (0.83) | CISD2ALDH1A1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023028117-A1 | METHODS OF TREATING CDGSH IRON SULFUR DOMAIN 2 INSUFFICIENCY-ASSOCIATED DISORDERS | YEH, TENG-KUANG (US) | 2023-03-02 | — | — | WO | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |