Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373375 | 0.82 | UCHL1 (0.41) | UCHL1KMT2AKDM4EALDH1A1MAPK1 | |
| SCHEMBL14115033 | 0.69 | UCHL1 (0.40) | UCHL1KMT2ACYP1A2CYP3A4LMNA | |
| SCHEMBL4811790 | 0.69 | CA12 (0.47) | UCHL1MAPTKMT2ACYP1A2CYP3A4 | |
| SCHEMBL4386058 | 0.69 | GRIA2 (0.53) | UCHL1 | |
| SCHEMBL18125046 | 0.68 | UCHL1 (0.41) | UCHL1MAPTKMT2AKDM4ECYP1A2 | |
| SCHEMBL14115035 | 0.68 | UCHL1 (0.41) | UCHL1KMT2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL15570368 | 0.67 | CA12 (0.45) | UCHL1MAPTKMT2AKDM4ECYP1A2 | |
| SCHEMBL4378867 | 0.67 | ALDH1A1 (0.52) | MAPTKMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1492360 | 0.67 | UCHL1 (0.42) | UCHL1MAPTKDM4ECYP1A2CYP3A4 | |
| SCHEMBL16830896 | 0.67 | UCHL1 (0.38) | UCHL1KMT2AKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |