Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.59 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.59 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290414 | 0.87 | MEN1 (0.75) | RXFP1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8289500 | 0.86 | RXFP1 (1.00) | RXFP1MAPTMEN1KMT2ATP53 | |
| SCHEMBL8288681 | 0.85 | RXFP1 (0.98) | RXFP1MAPTMEN1KMT2ATP53 | |
| SCHEMBL8289481 | 0.85 | MAPT (0.61) | RXFP1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL29334017 | 0.80 | MAPT (0.61) | RXFP1MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL3914076 | 0.79 | MAPT (0.73) | RXFP1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8290608 | 0.78 | MAPT (1.00) | RXFP1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8288667 | 0.78 | MAPT (1.00) | RXFP1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5453629 | 0.78 | PDE4B (0.65) | RXFP1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5455162 | 0.77 | MAPT (0.72) | RXFP1MAPTDUSP3PTPN5PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |