Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | AIP | O00170 | 1/20 | 0.53 |
| ▸ | SGTA | O43765 | 1/20 | 0.53 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.53 |
| ▸ | STIP1 | P31948 | 1/20 | 0.53 |
| ▸ | PPP5C | P53041 | 1/20 | 0.53 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.53 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288667 | 0.90 | MAPT (1.00) | MAPTRXFP1TP53THRBALDH1A1 | |
| SCHEMBL8290598 | 0.87 | MAPT (0.80) | MAPTRXFP1TP53THRBALDH1A1 | |
| SCHEMBL8288668 | 0.79 | MAPT (0.71) | MAPTRXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL13574989 | 0.78 | MAPT (0.72) | MAPTRXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL8289514 | 0.78 | AIP (0.69) | MAPTRXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL8289434 | 0.78 | RXFP1 (0.75) | MAPTRXFP1TP53ALDH1A1HPGD | |
| SCHEMBL8289505 | 0.77 | AIP (0.68) | MAPTRXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL3914076 | 0.77 | MAPT (0.73) | MAPTRXFP1TP53THRBALDH1A1 | |
| SCHEMBL8289822 | 0.76 | MAPT (0.68) | MAPTRXFP1ALDH1A1HPGDKDM4E | |
| SCHEMBL8290738 | 0.75 | MAPT (1.00) | MAPTRXFP1TP53THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |