SCHEMBL8289573

SCHEMBL8289573

CCOC(=O)c1c(NC(=O)c2ccc(C(C)(C)C)cc2)sc2c1CCCC2

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.79
GRIN2C Q14957 2/20 0.72
FLT3 P36888 1/20 0.71
CNR2 P34972 1/20 0.70
THRB P10828 1/20 0.70
KDM4E B2RXH2 4/20 0.69
MEN1 O00255 1/20 0.69
MITF O75030 1/20 0.69
KMT2A Q03164 1/20 0.69
KLF5 Q13887 1/20 0.69
TP53 P04637 2/20 0.69
ALDH1A1 P00352 3/20 0.68
USP2 O75604 1/20 0.68
ALOX15 P16050 1/20 0.68
CASP1 P29466 1/20 0.68
CASP7 P55210 1/20 0.68
HPGD P15428 3/20 0.65
HSD17B10 Q99714 3/20 0.65
MAPK1 P28482 2/20 0.65
TDP1 Q9NUW8 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7902217 0.91 MAPT (0.77) MAPTCNR2KDM4ETP53ALDH1A1
SCHEMBL7892222 0.90 MAPT (0.84) MAPTCNR2KDM4ETP53ALDH1A1
SCHEMBL3917114 0.89 MAPT (0.82) MAPTFLT3CNR2KDM4ETP53
SCHEMBL3914054 0.89 MAPT (0.82) MAPTFLT3CNR2KDM4EMEN1
SCHEMBL15272081 0.89 GRIN2C (0.79) MAPTGRIN2CFLT3KDM4EMEN1
SCHEMBL21247199 0.88 MAPT (1.00) MAPTFLT3CNR2KDM4ETP53
SCHEMBL16562058 0.88 MAPT (0.80) MAPTCNR2THRBKDM4EMEN1
SCHEMBL3916162 0.88 MAPT (0.80) MAPTCNR2KDM4ETP53ALDH1A1
SCHEMBL7903456 0.87 MAPT (0.79) MAPTCNR2THRBKDM4ETP53
SCHEMBL8289604 0.87 MAPT (0.78) MAPTFLT3CNR2KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3255083-B1 PREFORM, FIBER-REINFORCED COMPOSITE MATERIAL, AND METHOD FOR MANUFACTURING FIBER-REINFORCED COMPOSITE MATERIAL TORAY INDUSTRIES (JP) 2021-09-15 EP disclosed
US-10792869-B2 Preform, fiber-reinforced composite material, and method of manufacturing fiber-reinforced composite material TORAY INDUSTRIES, INC. (JP) 2020-10-06 US disclosed
US-10197933-B2 Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge FUJI XEROX CO., LTD. (JP) 2019-02-05 US disclosed
US-10082742-B2 Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge FUJI XEROX CO., LTD. (JP) 2018-09-25 US disclosed
US-20180264754-A1 PREFORM, FIBER-REINFORCED COMPOSITE MATERIAL, AND METHOD OF MANUFACTURING FIBER-REINFORCED COMPOSITE MATERIAL TORAY INDUSTRIES, INC. (JP) 2018-09-20 US disclosed
US-10054865-B2 Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge FUJI XEROX CO., LTD. (JP) 2018-08-21 US disclosed
US-9989872-B2 Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge FUJI XEROX CO., LTD. (JP) 2018-06-05 US disclosed
US-9989871-B2 Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge FUJI XEROX CO., LTD. (JP) 2018-06-05 US disclosed
EP-2825917-B1 TONER, METHOD FOR PRODUCING THE TONER, TWO-COMPONENT DEVELOPER, AND IMAGE FORMING APPARATUS RICOH CO LTD (JP) 2018-05-02 EP disclosed
US-20180059562-A1 ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPER, AND TONER CARTRIDGE FUJI XEROX CO., LTD. (JP) 2018-03-01 US disclosed
US-20180059564-A1 ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPER, AND TONER CARTRIDGE FUJI XEROX CO., LTD. (JP) 2018-03-01 US disclosed
US-9904198-B2 Electrostatic charge image developing toner, electrostatic charge image developer, and toner cartridge FUJI XEROX CO., LTD. (JP) 2018-02-27 US disclosed
US-20170227871-A1 IMAGE FORMING APPARATUS, ELECTROSTATIC CHARGE IMAGE DEVELOPER, AND ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER FUJI XEROX CO., LTD. (JP) 2017-08-10 US disclosed
US-20170184989-A1 ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPER, AND TONER CARTRIDGE FUJI XEROX CO., LTD. (JP) 2017-06-29 US disclosed
US-20150051220-A1 COMPOUNDS FOR USE IN THERAPY GLUCOX BIOTECH AB (SE) 2015-02-19 US disclosed
EP-2825165-A1 THIOPHENE-BASED COMPOUNDS EXHIBITING NOX4 INHIBITORY ACTIVITY AND USE THEREOF IN THERAPY Glucox Biotech AB (SE) 2015-01-21 EP disclosed
EP-2825917-A1 TONER, METHOD FOR PRODUCING THE TONER, TWO-COMPONENT DEVELOPER, AND IMAGE FORMING APPARATUS Ricoh Company, Ltd. (JP) 2015-01-21 EP disclosed
WO-2013135803-A1 THIOPHENE-BASED COMPOUNDS EXHIBITING NOX4 INHIBITORY ACTIVITY AND USE THEREOF IN THERAPY GLUCOX BIOTECH AB (SE) 2013-09-19 WO disclosed
WO-2013137368-A1 TONER, METHOD FOR PRODUCING THE TONER, TWO-COMPONENT DEVELOPER, AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2013-09-19 WO disclosed
WO-2005033102-A2 THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF AMPHORA DISCOVERY CORPORATION (US) 2005-04-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051220-A1 COMPOUNDS FOR USE IN THERAPY XDH, PNPO, OAT MAPT 1102/4885GRIN2C 790/4885FLT3 2108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.