Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | AIP | O00170 | 1/20 | 0.48 |
| ▸ | SGTA | O43765 | 1/20 | 0.48 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.48 |
| ▸ | STIP1 | P31948 | 1/20 | 0.48 |
| ▸ | PPP5C | P53041 | 1/20 | 0.48 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.48 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371517 | 0.85 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTPOLBHSD17B10 | |
| SCHEMBL918839 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTPOLBKMT2A | |
| SCHEMBL21247397 | 0.80 | TP53 (0.60) | ALDH1A1KDM4EMAPTPOLBKMT2A | |
| SCHEMBL21250170 | 0.77 | TP53 (0.54) | ALDH1A1KDM4EMAPTPOLBHSD17B10 | |
| SCHEMBL4227925 | 0.77 | MAPT (0.48) | ALDH1A1KDM4EMAPTPOLBKMT2A | |
| SCHEMBL7929684 | 0.75 | PDE4B (0.55) | ALDH1A1MAPTPOLBKMT2AHPGD | |
| SCHEMBL918266 | 0.75 | POLB (0.64) | ALDH1A1KDM4EMAPTPOLBHSD17B10 | |
| SCHEMBL6204554 | 0.75 | ALDH1A1 (0.61) | ALDH1A1KDM4EMAPTKMT2AHSD17B10 | |
| SCHEMBL21260713 | 0.72 | PDE4B (0.52) | ALDH1A1MAPTPOLBKMT2AHSD17B10 | |
| SCHEMBL21260738 | 0.72 | MAPT (0.54) | ALDH1A1KDM4EMAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |