Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.58 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.55 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635942 | 0.73 | ALDH1A1 (0.68) | NPSR1HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL16208829 | 0.71 | TSHR (0.67) | NPSR1HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL10016415 | 0.68 | NPC1 (1.00) | NPSR1ALDH1A1TSHRKMT2AMAPT | |
| SCHEMBL21104909 | 0.68 | ALDH1A1 (1.00) | NPSR1HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL17068788 | 0.67 | HSP90AA1 (0.74) | NPSR1HPGDALDH1A1TSHRMAPK1 | |
| SCHEMBL8289563 | 0.67 | ALDH1A1 (0.84) | NPSR1HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL13167282 | 0.66 | TP53 (1.00) | NPSR1ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL243554 | 0.66 | CA12 (0.74) | KMT2AUSP2MEN1MAPTPKM | |
| SCHEMBL10016428 | 0.64 | TP53 (0.80) | NPSR1HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL21447020 | 0.63 | RAB9A (0.64) | ALDH1A1TSHRMAPTPKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |