Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.75 |
| ▸ | FLT3 | P36888 | 5/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5455859 | 0.90 | MAPT (0.81) | MAPTTP53RXFP1FLT3THRB | |
| SCHEMBL8290598 | 0.88 | MAPT (0.80) | MAPTTP53RXFP1FLT3THRB | |
| SCHEMBL4135422 | 0.82 | HPGD (0.83) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL8289669 | 0.80 | HPGD (0.76) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL5457782 | 0.80 | ALDH1A1 (0.95) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL8288679 | 0.79 | HPGD (0.78) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL3125764 | 0.79 | ALDH1A1 (0.88) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL8289510 | 0.78 | ALDH1A1 (0.78) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL8288697 | 0.78 | ALDH1A1 (0.86) | MAPTTP53FLT3MEN1ALDH1A1 | |
| SCHEMBL5454380 | 0.78 | FLT3 (0.72) | MAPTTP53FLT3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |