Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453222 | 0.90 | FLT3 (1.00) | FLT3MAPTLMNAMEN1KMT2A | |
| SCHEMBL8288670 | 0.89 | FLT3 (0.80) | FLT3MAPTLMNAMEN1KMT2A | |
| SCHEMBL8288812 | 0.88 | FLT3 (0.79) | FLT3MAPTLMNAMEN1KMT2A | |
| SCHEMBL5460296 | 0.86 | FLT3 (0.80) | FLT3MAPTMEN1KMT2ATP53 | |
| SCHEMBL3914715 | 0.85 | FLT3 (0.74) | FLT3MAPTLMNAMEN1KMT2A | |
| SCHEMBL8290663 | 0.82 | FLT3 (1.00) | FLT3MAPTMEN1KMT2APOLB | |
| SCHEMBL8289432 | 0.82 | KMT2A (1.00) | FLT3LMNAMEN1KMT2ARXFP1 | |
| SCHEMBL1007246 | 0.82 | FLT3 (0.75) | FLT3MAPTLMNAMEN1KMT2A | |
| SCHEMBL4234573 | 0.81 | FLT3 (0.72) | FLT3MAPTLMNAMEN1KMT2A | |
| SCHEMBL8289853 | 0.81 | FLT3 (0.97) | FLT3MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |