Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CFTR | P13569 | 1/20 | 0.61 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015730 | 0.97 | KCNH2 (0.71) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5455065 | 0.89 | MEN1 (0.79) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5462791 | 0.89 | FLT3 (0.72) | FLT3MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5467902 | 0.89 | FLT3 (0.72) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5450860 | 0.89 | MEN1 (0.78) | FLT3MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5450867 | 0.88 | FLT3 (0.67) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5460074 | 0.88 | MEN1 (0.67) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5455531 | 0.88 | FLT3 (0.61) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5448370 | 0.87 | MEN1 (0.68) | FLT3KCNH2MAPTMEN1KMT2A | |
| SCHEMBL5453610 | 0.87 | FLT3 (0.77) | FLT3MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210186943-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | SPIRAL THERAPEUTICS INC. | 2021-06-24 | — | — | US | disclosed |
| US-20210186943-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | SPIRAL THERAPEUTICS INC. | 2021-06-24 | — | — | US | disclosed |
| EP-3810146-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | Otonomy, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| US-8232314-B2 | Compounds that protect against sensory hair cell death | UNIVERSITY OF WASHINGTON (US) | 2012-07-31 | — | — | US | disclosed |
| US-8232314-B2 | Compounds that protect against sensory hair cell death | UNIVERSITY OF WASHINGTON (US) | 2012-07-31 | — | — | US | disclosed |
| US-20090023751-A1 | COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH | UNIVERSITY OF WASHINGTON (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090023751-A1 | COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH | UNIVERSITY OF WASHINGTON (US) | 2009-01-22 | — | — | US | disclosed |
| US-20060188445-A1 | Assay for compounds that protect against sensory hair cell death and compounds identified by same | FRED HUTCHINSON CANCER RESEARCH CENTER | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060188445-A1 | Assay for compounds that protect against sensory hair cell death and compounds identified by same | AIFM1, CASP3, CASP10 | FLT3 4847/4885KCNH2 1321/4885MAPT 3505/4885 |
| US-20210186943-A1 | OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY | TRPV1, TRPV2, TRPA1 | FLT3 3252/4885KCNH2 958/4885MAPT 1737/4885 |
| US-20090023751-A1 | COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH | AIFM1, CASP3, BAD | FLT3 4803/4885KCNH2 1127/4885MAPT 3529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.